Pengaruh Pemberian Nata De Coco Terhadap Kadar Kolesterol LDL dan HDL pada Tikus Hiperkolesterolemi

Abstract

Introduction: The rising of LDL cholesterol level and the HDL cholesterol level declined to increase cardiovascular disease risk. Diet is the most efective method to decrease the LDL increase cardiovascular disease risk. Diet is the most efective method to decrease the LDL cholesterol level by increase dietary fiber intake withnata de coco’s intake. Thus a study was to prove the effect of nata de coco of different dosages on LDL and HDL cholesterol of hypercholesterolemic rats.
Methods: An true experimental study using control group with pre and post test design was carried out to already made-hypercholesterolemic Sprague Dawley rats. They received 0,88
g/d, 1,76 g/d, 2,65 g/d, and 3,53 g/d dried nata de coco. LDL and HDL cholesterol were measured before and after the treatment, using CHOD-PAP methods respectively. Data were analyzed using paired t-test and repeated measurement Anova, followed by LSD at 95% confidence level.

Result: The present of nata de coco dosages in 3,53 gwas able significantly to reduce the LDL cholesterol from 135,83 mg/dl to 20,45 mg/dl and increase the HDL cholesterol from 49,51 mg/dl, 50,59 mg/dl, and 49,73 mg/dl to 67,20 mg/dl, 74,30 mg/dl, and 82,58 mg/dl of the experiment rats.

Conclusion: There was decreasing concentration of LDL cholesterol 115.38 mg/dland was increasing concentration of HDL cholesterol 32,85 mg/dl after given dried nata de coco in 3,53 g per day during 14 days.