Manfaat Isoflavon dalam Produk Kedelai Menanggulangi Diabetes serta Mencegah Obesitas dan Osteoporosis

Authors

  • Andi Imam Arundhana Program Studi Ilmu Kesehatan Masyarakat, Minat Gizi dan Kesehatan, Fakultas Kedokteran, Universitas Gadjah Mada , Indonesia

Keywords:

Kacang kedelai, isoflavon, antioksidan, penyakit kronik

Abstract

In Indonesia, processed of soy products such as tempe, tofu, soy milk and some other foods can be obtained easily. Soybean contains isoflavones, protein fiber, has a low glycemic index, and classified as a functional food. It is the underlying beneficiary of soybeans specifically in the management of obesity, diabetes and other co-morbidities. Several RCT studies to examine the effects of isoflavones from soy products, suggesting that isoflavones reduce the risk of health problems such as breast and prostate cancer, coronary heart disease, prevent the loss of bone density in the elderly, and has the potential to prevent obesity and diabetes. Not only the source of isoflavones from soy products but can also be obtained from nuts, and wheat although fewer in number than soybeans. As for the daily needs of the individual isoflavones, there is no reference that shows the limits on isoflavones. However, the more antioxidants and anti-inflammatory in the body better. Nonetheless, the source of intake of isoflavones is also worth noting, because the food sources of isoflavones contain high protein and if the protein intake constantly excessive will impact the health of the kidneys and increases in serum albumin levels. We recommend that you keep referring to the basic needs of an individual protein, and the selection of food sources of protein derived from soy products so protein and isoflavones daily needs can be met. 

References

Orgaard A., and Lotte J. The Effect of Soy Isoflavones on Obesity. Experimental Biology and Medicine 2008; (233): 1066-1080.

Alrasyid, Harun. Peran Isoflavon Tempe Kedelai, Fokus pada Obesitas dan Komorbid. Majalah Kedokteran Nusantara 2007; (40)3:203-210.

Pawiroharsono, Suyanto. Prospek dan Manfaat Isoflavon untuk Kesehatan. Direktorat Teknologi Bioindustri. Jakarta; Badan Pengkajian dan Penerapan Teknologi: 2001.

Posadzki P., Lee M.S., Onakpoya I., Lee H.W., Ko B.S., and Ernst E. Dietary Supplements and Prostate Cancer: A Systematic Review of Double-blind, Placebo-controlled Randomized Clinical Trials. Maturitas (2013); 1-6. Liu, 2009

Liu J., Ho SC., Su Y., Chen W., Zhang C., Chen Y. Effect of Long-term Intervention of Soy Isoflavones on Bone Mineral Density in Women: A Meta analysis of Randomized Controlled Trials. Bone 2009; (44): 948-953.

Orgaard A, Jensen L: The Effects of Soy Isoflavones on Obesity. Exp Bio Med 2008, 233:1066-1080.

Mueller et al., 2012 Mueller N.T., Odegaard A.O., Gross M.D., Woon-Puay, Yu M.C., Jian-Min., and Pereira M.A. Soy Intake and Risk of Type 2 Diabetes Mellitus in Chinese Singaporeans: Soy Intake and Risk of Type 2 Diabetes. Eur J Nutr. 2012

Goodman-Gruen D, Kritz-Silverstein D. Usual Dietary Isoflavone Intake is Associated with Cardiovascular Disease Risk Factors in Postmenopausal Women. J Nutr. 2001;131:1202-6.

Liu, Zhao-min, Chen, Ho S.C., Ho Y.P., and Woo J. Effects of Soy Protein and Isoflavones on Glycemic Control and Insulin Sensitivity: A 6-mo Double-blind, Randomized, Placebo-controlled Trial in Postmenopausal Chinese Women with Prediabetes or Untreated Early Diabetes. Am J Clin Nutr 2010;91:1394–401.

Curtis P.J., Samson M., Potter J., Dhatariya K., Kroon P.A., Cassidy A. Chronic Ingestion of Flavan-3-ols and Isoflavones Improves Insulin Sensitivity and Lipoprotein Status and Attenuates Estimated 10-Year CVD Risk in Medicated Postmenopausal WomenWith Type 2 Diabetes. Diabetes care 2012; (35): 226-232.

Ricci E, Cipriani S, Chiaffarino F,Malvezzi M, Parazzini F. Effects of Soy Isoflavones and Genistein on Glucose Metabolism in Perimenopausal and Pascamenopause non- Asian Women: a Meta-analysis of Randomized Controlled Trials. Menopause 2010;17:1080–1086.

Bahthena and Velasquez. Beneficial Role of Dietary Phytoestrogen in Obesity and Diabetes 1, 2. Am J Clin Nutr 2002; (7) 6: 1191-1201.

Beresford SAA, Weiss NS, McKnight B. Risk of Endometrial Cancer in Relation to Use of Oestrogen Combined with Cyclic Progestagen Therapy Pascamenopause 1997;349:458–61.

Manson JE, Hsia J, Johnson KC, et al; Women’s Health Initiative Investigators. Estrogen Plus Progestin and the Risk of Coronary Heart Disease. N Engl J Med 2003;349:523–34.

Rossouw JF, Anderson GL, Prentice, et al; Writing Group for the Women’s Health Initiative Investigators. Risks and Benefits of Estrogen Plus Progestin in Healthy Pascamenopause Women: Principal Results from the Women’s Health Initiative Randomized Controlled Trial. JAMA 2002; 288:321–33.

Alekel DL., Van Loan, Koehler K.J., Hanson L.N., Stewart J.W., Hanson K.B., Kurzer M.S., and Peterson C.T. The Soy Isoflavones for Reducing Bone Loss (SIRBL) Study: a 3-year RCT in Postmenopausal Women. Am J Clin Nutr 2010;91:218–30.

Setchell KD, Brown NM, Lydeking-Olsen E. The Clinical Importance of the Metabolite Equol-a Clue to the Effectiveness of Soy and Its Isoflavones. J Nutr. 2002;132:3577–84.

Mahmudati Nurul, 2008. Activation Estrogen receptor αExtracelluler Signal Regulated Kinase (ERK1/2) Expression on Osteoblast in Influencing Bone Density in The Female Young Rat after Exercise Training. DISERTASI. UNAIR 19.

Ma DF., Qin LQ., Wang PY., Katoh R. Soy Isoflavone Intake Inhibits Bone Resorption and Stimulates Bone Formation in Menopausal Women: Meta analysis of Randomized Controlled Trials. Eur J Clin Nutr 2008; (62):155–61. 20.

Wu Jian, Wang X., Chiba H., Higuchi M., Nakatani T., Ezaki O., Cui H., Yamada K., Ishimi Y. Combined Intervention of Soy Isoflavones and Moderate Exercise Prevents Body Fat Elevation & Bone Loss in Ovarioectomized Mice. J.metabol 2004; (53) 7:942-948.

Ma DF, Qin LQ, Wang PY, Katoh R. Soy Isoflavone Intake Increases Bone Mineral Density in the Spine of Menopausal Women: Meta-analysis of Randomized Controlled Trials. Clin Nutr. 2008;27:57 64. 22.

Taku K, Melby MK, Takebayashi J, Mizuno S, Ishimi Y, Omori T, Watanabe S. Effect of Soy Isoflavone Extract Supplements on Bone Mineral Density in Menopausal Women:meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2010;19:33–42. 23.

Bray, George A. The Metabolic Syndrome and Obesity. New York; Human press: 2007.

Allison, Gadburry, Schwartz, Murugesan, Kraker, Heshka, Fontaine, and Heymsfield. A Novel Soy-based Meal Replacement Formula for Weight Loss among Obese Individuals: a randomized controlled clinical trial. European Journal of Clinical Nutrition 2003; (57): 514–522

Crespillo A., Alonso M., Vida M., Pavóni F.J., Serrano A., Rivera P., Romero Zerbo, Fernández-Llebrez, Martínez A., Pérez-Valero, Bermúdez-Silva, Suárez J., and FR de Fonseca. Reduction of Body Weight, Liver Steatosis and Expression of Stearoyl-CoA Desaturase 1 by the Isoflavone Daidzein in Diet induced Obesity. British Journal of Pharmacology (2011) 164 1899–1915.

Michael MR, Wolz E, Davidovich A, Pfannkuch F, Edwards JA, Bausch J (2006). Acute, Subchronic and Chronic Safety Studies with Genistein in Rats. Food Chem Toxicol 44: 56–80.

Na XL, Ezaki J, Sugiyama F, Cui HB, Ishimi Y (2008). Isoflavone Regulates Lipid Metabolism Via Expression of Related Genes in OVX Rats Fed on a High-fat. Diet 21: 357–364

Davis J, Higginbotham A, O’Connor T, Moustaid-Moussa N, Tebbe A, Kim YC et al. (2007). Soy Protein and Isoflavones Influence Adiposity and Development of Metabolic Syndrome in Obese Male ZDF Rat. Ann Nutr Metab 51: 42–52. 29.

Guo Y, Wu G, Su X, Yang H, Zhang J (2009). Antiobesity Action of a Daidzein Derivative on Male Obese Mice Induced by a High-fat Diet. Nutr Res 29: 656–663.

Kim MH, Park JS, Jung JW, Byun KW, Kang KS, Lee YS (2010). Daidzein Supplementation Prevents Non-alcoholic Fatty Liver Disease through Alternation of Hepatic Gene Expression Profiles and Adipocyte Metabolism. Int J Obes doi:10.1038/ijo.2010.256 [Epub ahead of print].

Messina M, Gardner C, Barnes S. Gaining Insight into the Health Effects of Soy but a Long Way Still to Go: Commentary on the Fourth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease. J Nutr 2002; 132: 547S–551S.

Clarkson TB. Soy, Soy Phytoestrogens and Cardiovascular Disease. J Nutr 2002; 132: 566S–569S.

Cassidy A, Hooper L. Phytoestrogens and cardiovascular disease. J Br Menopause Soc 2006; 12: 49–56. 34.

Zhang C, Ho SC, Lin F, Cheng S, Fu J, Chen Y. Soy Product and Isoflavone Intake and Breast Cancer Risk Defined by Hormone Receptor Status. Cancer Sci 2010; 101: 501–507.

Evans M, Lin X, Odle J, McIntosh M: Trans-10, cis-12 Conjugated Linoleic Acid Increases Fatty Acid Oxidation in 3T3-L1 preadipocytes. 2002,132:450- 455. J Nutr

Anderson JW, Johnstone BM, Newell MEC. Meta Analysis of The Effects of Soy Protein Intake on Serum Lipids. N Eng J Med 1995; 276–82. 37.

Muthyala, R. S.; Ju, J.-H.; Sheng, S.; Williams, L. D.; Doerge, D. R.; Katzenellenbogen, B. S.; Helferich, W. G. & Katzenellenbogen, J. A. Equol, a Natural Estrogenic Metabolite from Soy Isoflavones: Convenient Preparation and Resolution of R- and Sequols and Their Differing Binding and Biological Activity through Estrogen Receptors. Bioorganic & Medicinal Chemistry 2004; 12: 1559 1567

Downloads

Published

2025-05-28

How to Cite

Arundhana, A. I. (2025). Manfaat Isoflavon dalam Produk Kedelai Menanggulangi Diabetes serta Mencegah Obesitas dan Osteoporosis. Berkala Ilmiah Mahasiswa Gizi Indonesia, 2(1), 7–15. Retrieved from https://bimgi.or.id/index.php/bimgi/article/view/105

Citation Check